Endothelial-immune crosstalk contributes to vasculopathy in non-alcoholic fatty liver disease
C.-Y. Ng, K. L. Lee, M. D. Muthiah, K. X. Wu, F. Chioh, K. Tan, G. Soon, A. Shabbir, W. M. Loo, Z. S. Low, Q. Chen, N. S. Tan, H.-H. Ng, Y. Y. Dan, C. Cheung
This study investigates endothelial-immune interactions in NAFLD, showing increased chemokine expression and immune cell infiltration, and demonstrates that targeting the CXCL12-CXCR4 axis can restore endothelial barrier function.
bioRxiv · Dec 13, 2021Cell Biology