Accelerated single cell seeding in relapsed multiple myeloma
H. J. Landau, V. Yellapantula, B. J. Diamond, E. H. Rustad, K. Maclachlan, G. Gundem, J. Medina-Martinez, J. E. Arango Ossa, M. Levine, Y. Zhou, K. L. Rajya, P. Baez, M. Attiyeh, A. Makohon-Moore, L. Zhang, , F. Maura
This study uses whole genome sequencing to show that relapsed multiple myeloma exhibits accelerated systemic seeding driven by chemotherapy-induced mutations and clonal expansion of single myeloma cells.
bioRxiv · Feb 25, 2020Cancer Biology