Author

K. L. Sarachan

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Biochemistry· 1

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Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. C. Raimer· 1 shared A. G. Matera· 1 shared A. M. Spring· 1 shared G. D. Van Duyne· 1 shared K. Gupta· 1 shared M. C. Johnson· 1 shared N. S. Ninan· 1 shared R. Sharp· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

A. C. Raimer

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1 paper

Recent·Most cited

Assembly of higher-order SMN oligomers is essential for metazoan viability and requires an exposed structural motif present in the YG zipper dimer

K. Gupta, Y. Wen, N. S. Ninan, A. C. Raimer, R. Sharp, A. M. Spring, K. L. Sarachan, M. C. Johnson, G. D. Van Duyne, A. G. Matera

This study identifies a structural motif in the SMN YG box essential for higher-order oligomerization, which is critical for viability and linked to SMA in animal models.

bioRxiv · Nov 7, 2020Biochemistry