Low normal factor V enhances thrombin generation in hemophilia A through a substrate competition mechanism with factor Xa
D. M. Monroe, C. Baird, J. A. Peterson, A. E. Mast, M. Manco-Johnson, M. Stobb, S. Sindi, A. L. Fogelson, K. Leiderman, K. Neeves
The paper shows low normal factor V levels enhance thrombin generation in hemophilia A through reduced substrate competition with factor Xa for factor VIII activation.
bioRxiv · Jun 27, 2022 · PreprintBiochemistry