Understanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneity
A. F. Feder, K. N. Harper, C. J. Brumme, P. S. Pennings
The paper analyzes HIV resistance evolution patterns under temporal and spatial drug heterogeneity models, showing resistance develops even after long-term therapy and in predictable sequences.
bioRxiv · Jul 19, 2021Evolutionary Biology