Polygenic mutations model the pleiotropic disease of Fanconi Anemia
K. Schlacher, K.-H. Tomaszowski, S. Roy, C. Keshvani, M. Ott, C. DiNardo, D. Schindler
This study shows that mutations in two FANC genes in mice model the severity and heterogeneity of Fanconi Anemia, revealing functional synergism of polygenic mutations.
bioRxiv · Sep 1, 2020 · PreprintCancer Biology