Clustered Protocadherin Cis-interactions are Required for Homophilic Combinatorial Cell-Cell Recognition Underlying Neuronal Self-Avoidance
G. Wiseglass, N. Boni, K. Smorodinsky-Atias, R. Rubinstein
The paper shows that cis-interactions of clustered protocadherins are essential for combinatorial cell-cell recognition, and mismatched isoforms disrupt trans complex stability, leading to neuronal self-avoidance.
bioRxiv · Nov 11, 2023 · PreprintBiochemistry