BiophysicsbioRxivPreprint
A mechanistic model improves off-target predictions and reveals the physical basis of SpCas9 fidelity
B. Eslami-Mossallam, M. Klein, C. v. d. Smagt…·M. Depken
This paper develops a mechanistic model to predict SpCas9 off-target activity and explains its structural basis for fidelity.
DOI 10.1101/2020.05.21.108613