Computationally-guided tuning of ligand sensitivity in a GPCR-based sensor
D. Keri, R. B. Cola, K. Zacharoula, T. Patriarchi, P. Barth
The paper enhances the sensitivity of a GPCR-based dopamine sensor using computational design, achieving up to 15-fold increased potency for norepinephrine.
bioRxiv · Sep 21, 2021 · PreprintBioengineering