Author

T. Patriarchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:deep learning· 2 Assay:fluorescence / live-cell microscopy· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

L. Duffet· 2 shared A. Breuer· 1 shared A. Gresch· 1 shared A. Gupta· 1 shared A. Tonnesen· 1 shared C. G. Shuttle· 1 shared C. G. Tate· 1 shared D. Benke· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

L. Duffet

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multimodal intrinsic activation of GPCRs in ultrastable plasma membrane nanodomains

G. Kockelkoren, J. Carstensen, L. Lauritsen, E. Kazepidou, A. Tonnesen, C. G. Shuttle, P. S. Kaas, A. Gupta, A. Breuer, S. G. F. Rasmussen, L. Duffet, T. Warne, T. Patriarchi, C. G. Tate, M. Uline, D. Stamou

This paper quantifies GPCR intrinsic activation at the plasma membrane, revealing spatial multimodality with most receptors showing negligible spontaneous activation.

bioRxiv · Feb 28, 2024 · PreprintBiophysics

Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution

L. Duffet, E. T. Williams, A. Gresch, S. Chen, M. A. Bhat, D. Benke, N. Hartrampf, T. Patriarchi

This paper introduces GLPLight1, a genetically-encoded sensor for high spatiotemporal resolution visualization of GLP1R activation, and demonstrates its use in optical control of receptor activation.

bioRxiv · Feb 14, 2023 · PreprintBiochemistry

Computationally-guided tuning of ligand sensitivity in a GPCR-based sensor

D. Keri, R. B. Cola, K. Zacharoula, T. Patriarchi, P. Barth

The paper enhances the sensitivity of a GPCR-based dopamine sensor using computational design, achieving up to 15-fold increased potency for norepinephrine.

bioRxiv · Sep 21, 2021 · PreprintBioengineering