HIV-1 Vif disrupts phosphatase feedback regulation at the kinetochore, leading to a pronounced pseudo-metaphase arrest
Dhaval Ghone, Edward L. Evans, Madison Bandini, Kaelyn G Stephenson, Nathan M. Sherer, Aussie Suzuki
This study shows HIV-1 Vif causes a pseudo-metaphase arrest by reducing PP1 and PP2A at kinetochores, distinct from Vpr-induced prometaphase arrest.
eLife · Mar 13, 2025Peer-reviewedMicrobiology