Exploring ex vivo modulation of fibrosis in discarded human donor kidneys
Carolina Campos Pamplona, Cristina Ballester Bergada, Christopher L. Jaynes, Tim L. Hamelink, Veerle A. Lantinga, Baran Ogurlu, Petra J. Ottens, Kai van Hateren, Jan‐Luuk Hillebrands, Peter Olinga, Daan Johannes Touw, Henri G. D. Leuvenink, Cyril Moers, L. Leonie van Leeuwen
This study evaluates the anti-fibrotic effects of galunisertib in discarded human kidneys using ex vivo perfusion and tissue culture, showing reduced fibrosis-related mRNA expression with continuous treatment.
bioRxiv · Jul 31, 2025 · PreprintPharmacology & Toxicology