Glucagon-like peptide-1 receptor agonist, semaglutide, attenuates intravenous self-administration of fentanyl in female rats
Kaitlyn E Rojas, Sarah Gee, Chris Wernette, Eric X Wang, Emily T Nguyen, Jacques D. Nguyen
This study shows semaglutide reduces fentanyl self-administration and withdrawal-like behavior in female rats, suggesting its potential as a treatment for opioid use disorder.
bioRxiv · May 21, 2026 · PreprintPharmacology & Toxicology