Using graph-based model to identify cell specific synthetic lethal effects
Mengchen Pu, Kaiyang Cheng, Xiaorong Li, Yucui Xin, Lanying Wei, Sutong Jin, Weisheng Zheng, Gongxin Peng, Qihong Tang, Jielong Zhou, Yingsheng Zhang
This paper introduces a deep learning model using graph-based representation to predict cell-specific synthetic lethal gene pairs, enhancing cancer precision medicine.
Computational and Structural Biotechnology Journal · Jan 1, 2023Peer-reviewedBioinformatics