Collective biosynthesis of plant spirooxindole alkaloids through enzyme discovery and engineering
Danni Chu, Hongkui Wang, Zhiwen Nie, Kang-Li Li, Jiaqing Cao, Meijing Yang, Qin Yin, Yang Gu, Yindi Jiang
The paper identifies and engineers enzymes to enable collective biosynthesis of spirooxindole alkaloids, expanding substrate scope and producing new derivatives.
Journal of the American Chemical Society · Jun 12, 2025Peer-reviewedBiochemistry