Kankana Bhattacharjee

Constraint Network Analysis of Global and Local Rigidity in Wild-Type EGFR: Apo vs Gefitinib-Bound States

This study uses Constraint Network Analysis to compare the mechanical rigidity of wild-type EGFR in apo and gefitinib-bound states, finding that ligand binding causes localized rigidification without large-scale structural reorganization.

Identification of Key Regulators in Pancreatic Ductal Adenocarcinoma using Network theoretical Approach

The paper identifies key regulators in PDAC using network analysis, revealing their involvement in specific pathways and functions, and suggests potential therapeutic targets.