T cell intrinsic 4-1BB signals induce Prdm16 to increase effector and memory T cell numbers during respiratory influenza infection
Seungwoo Lee, Karen Yeung, Carolina de Amat Herbozo, Razieh Eshraghisamani, Alina D. Dorogy, Tania H. Watts
This study shows that 4-1BB signaling in T cells during influenza infection induces Prdm16, enhancing effector and memory CD8 T cell numbers through mitochondrial and metabolic pathways.
bioRxiv · Apr 6, 2026 · PreprintImmunology