Karl Tayeb

Cell-type and dynamic state govern genetic regulation of gene expression in heterogeneous differentiating cultures

The paper identifies expression quantitative trait loci in 29 cell-types from heterogeneous differentiating cultures and characterizes regulatory dynamics across differentiation trajectories.

GoM DE: interpreting structure in sequence count data with differential expression analysis allowing for grades of membership

This paper introduces GoM DE, a differential expression analysis method that allows cells to have partial membership in multiple groups, improving the interpretation of structure in single-cell sequencing data.

Uncovering context-specific genetic-regulation of gene expression from single-cell RNA-sequencing using latent-factor models

This paper introduces SURGE, a method to discover context-specific eQTLs from single-cell RNA-seq data, showing its relevance in disease through colocalization analysis.

Redefining tissue specificity of genetic regulation of gene expression in the presence of allelic heterogeneity

The paper introduces CAFEH, a method to better identify causal regulatory variants across tissues by accounting for allelic heterogeneity and linkage disequilibrium in eQTL data.