Protein language model pseudolikelihoods capture features of in vivo B cell selection and evolution
Daphne van Ginneken, Anamay Samant, Karlis Daga-Krumins, Wiona Sophie Glänzer, Andreas Agrafiotis, Evgenios Kladis, Sai T. Reddy, Alexander Yermanos
This study shows that protein language model pseudolikelihoods correlate with B cell selection features like SHM and isotype usage, but not binding affinity, in vivo.
Briefings in Bioinformatics · Jul 1, 2025Peer-reviewedBioinformatics