Whole Genome Sequencing of Plasmodium vivax Isolates Reveals Frequent Sequence and Structural Polymorphisms in Erythrocyte Binding Genes
Anthony Ford, Daniel Kepple, Beka Raya Abagero, Jordan Connors, Richard D. Pearson, Sarah Auburn, Sisay Getachew, Colby T. Ford, Karthigayan Gunalan, Louis H. Miller, Daniel A. Janies, Julian C. Rayner, Guiyun Yan, Delenasaw Yewhalaw, Eugenia Y. Y. Lo
This study analyzes whole genome sequences of Plasmodium vivax isolates from Ethiopia to identify sequence and structural polymorphisms in erythrocyte binding genes, revealing positive selection and gene copy number variations associated with host-parasite interactions.
PLoS neglected tropical diseases · Oct 12, 2020Peer-reviewedGenomics