Richard D. Pearson

The paper identifies pfcrt copy number amplification as a new antimalarial resistance mechanism in Plasmodium falciparum and develops a TaqMan assay for its detection.

The paper analyzes amplicon sequencing data from 17,384 Plasmodium falciparum samples in West Africa to characterize antimalarial resistance patterns and their geographic distribution.

The paper analyzes whole-genome sequencing data from Plasmodium falciparum isolates in Ethiopia and sub-Saharan Africa to characterize genetic diversity and resistance markers.

Pf-PeptideFilter is a web-based tool that filters peptide vaccine candidates for Plasmodium falciparum using genomic and transcriptomic data to prioritize immunogenic targets.

The paper shows that regional genetic variation in Plasmodium falciparum affects transmissibility to different mosquito species by altering midgut adhesion interactions.

The paper analyzes the evolution and prevalence of dhfr and dhps resistance alleles and haplotypes across Africa using whole genome data from multiple countries.

This paper aggregates spatiotemporal data on 112,933 Plasmodium falciparum samples to track the global spread of artemisinin resistance, highlighting its emergence in East Africa and the role of genomic surveillance.

Pf-HaploAtlas provides an interactive web tool for analyzing spatiotemporal genomic variation in Plasmodium falciparum using data from 16,203 samples across 33 countries.

The paper identifies a cryptotype in Plasmodium falciparum genomes across Africa, characterized by a complex genetic background that is geographically widespread but genetically distinct.

The paper develops a molecular barcode and online tool to identify and map imported Plasmodium vivax infections using SNP analysis and machine learning.

This study implements a Nanopore sequencing workflow for P. falciparum genomic surveillance in Ghana, identifying drug resistance patterns and vaccine antigen variations.

This study identifies pfaat1 as a key gene in chloroquine resistance evolution in malaria parasites, showing it modulates resistance and fitness through amino acid transport.

The paper investigates the association between host sickle cell haemoglobin and parasite genetic variation in malaria severity, finding that parasite alleles linked to HbS show strong linkage disequilibrium and frequency covariation with HbS.

This study analyzes whole genome sequences of Plasmodium vivax isolates from Ethiopia to identify sequence and structural polymorphisms in erythrocyte binding genes, revealing positive selection and gene copy number variations associated with host-parasite interactions.

The paper presents an open dataset of Plasmodium falciparum genome variation from 7,000 worldwide samples, revealing widespread drug resistance and geographic genetic differentiation.

The paper sequences genomes of 765 malaria vector mosquitoes to study genetic diversity and insecticide resistance.