Rapid spatial cognition in mice, with and without neocortex and hippocampus
Jieyu Zheng, Rogério Guimarães, Zeynep Turan, Anwesha Das, Jennifer Yuan-Shih Hu, Katelyn Sadorf, Pietro Perona, Markus Meister
Naive mice learn a 9-turn route in a reconfigurable 3D maze within about 20 rewards; mutants lacking neocortex and hippocampus also learn, remember and generalize, though early exploration is inefficient.
bioRxiv · Sep 29, 2026 · PreprintNeuroscience✦ In-depth digest