A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin-associated histone modifications
Morgan E. Levine, Ross A. McDevitt, Margarita V. Meer, Kathy A Perdue, Andrea Di Francesco, Theresa Meade, Colin P. Farrell, Kyra Thrush, Meng Wang, Christopher Dunn, Matteo A. Pellegrini, Rafael de Cabo, Luigi Ferrucci
This paper develops a rat epigenetic clock (DNAmAge) that correlates with age and phenotypic aging, and identifies histone modifications linked to its signal.
bioRxiv · May 13, 2020 · PreprintMolecular Biology