Margarita V. Meer

The paper develops 11 system-specific methylation clocks from blood samples to quantify aging heterogeneity across physiological systems and identifies aging subtypes with distinct disease patterns.

The paper identifies compounds that extend mouse lifespan and healthspan using a biomarker-driven platform integrating gene expression, chemical screening, and lifespan studies.

The paper identifies and characterizes age-invariant genes across multiple tissues in mice, finding they are stable across the lifespan and have distinct molecular features.

The paper introduces TIME-Seq, a low-cost method for epigenetic age prediction, and validates it on mouse and human samples, showing improved scalability and accuracy.

This paper develops a rat epigenetic clock (DNAmAge) that correlates with age and phenotypic aging, and identifies histone modifications linked to its signal.

The paper shows that inducing DNA breaks accelerates aging-related chromatin changes and loss of cell identity in mammals.

This paper demonstrates that epigenetic reprogramming using OSK genes can reverse age-related and injury-induced vision loss in mice by resetting DNA methylation patterns and promoting axon regeneration.