Multistability and predominant double-positive states in a four node mutually repressive network: a case study of Th1/Th2/Th17/T-reg differentiation
Atchuta Srinivas Duddu, Elizabeth Andreas, BV Harshavardhan, Kaushal Grover, Vivek Raj Singh, Kishore Hari, Siddharth Jhunjhunwala, Bree Cummins, Tomáš Gedeon, Mohit Kumar Jolly
The paper studies a four-node mutually repressive network, showing it allows for six stable double-positive states and applies this to explain Th1/Th2/Th17/Treg differentiation.
bioRxiv · Jan 30, 2024 · PreprintSystems Biology