Siddharth Jhunjhunwala

The paper shows that specific ligands on phagocytosed cargo activate p38 MAPK signaling, enhancing phagosome maturation and lysosomal delivery in macrophages.

The paper shows chronic inflammation increases immature neutrophils, which worsen immunopathology during new inflammatory events, and suggests targeting these cells as a therapeutic strategy.

This study shows that unmodified mRNA can be effectively delivered to immune cells ex vivo via a non-endosomal route without needing nucleoside modifications.

This study shows immune cell attachment on medical device surfaces promotes bacterial biofilm formation, and introduces an antimicrobial composite that converts immune cells into bactericidal effectors.

This study investigates the structural and functional dynamics of Staphylococcus aureus α-hemolysin during membrane interaction, revealing its role in cell necrosis and pore formation.

The paper studies a four-node mutually repressive network, showing it allows for six stable double-positive states and applies this to explain Th1/Th2/Th17/Treg differentiation.

The paper models a three-node regulatory network to explain phenotypic switching and heterogeneity in Th1/Th2/Th17 cell differentiation, showing how epigenetic repression influences transition rates between phenotypes.

The paper investigates a network of three mutually repressing master regulators, showing it can lead to multiple stable cell states and applies this to understand T cell differentiation.

This paper develops a mechanistic model of SARS-CoV-2 and immune system interactions to explain diverse clinical outcomes and guide drug combination strategies.