Sex-Specific Modulation of Gene Expression by 17beta-Estradiol in Human Meniscal Cells: Pathways to Targeted Osteoarthritis Therapies
Youngmin Yu, John M. Vergis, Hunter Eby, Mario Markho, Jonathan P. Kopacz, Kayla M. Cartwright, Michael Hershey, Jiayong Liu, Robert Erne McCullumsmith
This study reanalyzes RNA-seq data to show sex-specific effects of 17beta-estradiol on gene expression in human meniscal fibrochondrocytes, identifying distinct transcriptional programs in males and females.
bioRxiv · Jul 28, 2026 · PreprintBioinformatics