Hunter Eby

Sex-Specific Modulation of Gene Expression by 17beta-Estradiol in Human Meniscal Cells: Pathways to Targeted Osteoarthritis Therapies

This study reanalyzes RNA-seq data to show sex-specific effects of 17beta-estradiol on gene expression in human meniscal fibrochondrocytes, identifying distinct transcriptional programs in males and females.

Characterization of active kinase signaling pathways in astrocytes and microglia

The paper characterizes kinase signaling pathways in astrocytes and microglia, revealing cell- and sex-specific activity patterns that differ from transcriptional profiles.

Neuronal alterations in AKT isotype expression in schizophrenia

This study identifies elevated mRNA expression of AKT isotypes in schizophrenia neurons, suggesting a potential decoupling of transcript and protein levels, with sex-specific differences and involvement of related signaling components.

Molecular Neurobiology of Loss

This study investigates the molecular mechanisms of psychological loss in rats using a multi-omics approach, finding changes in microglia and extracellular matrix linked to impaired emotional processing.

Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy.

The paper analyzes transcriptomic data from pilocarpine-induced temporal lobe epilepsy to identify predictive biomarkers and cellular mechanisms, revealing aberrant interactions between cell types and potential drug targets.

Similarities and dissimilarities between psychiatric cluster disorders

This study compares psychiatric disorders using pathway, cell-type, drug-target, and chromosomal analyses to identify common and distinct features across an unbiased cluster of disorders.

Kaleidoscope: A New Bioinformatics Pipeline Web Application for In Silico Hypothesis Exploration of Omics Signatures

Kaleidoscope is a web application that provides access to omics databases and tools for in silico hypothesis exploration, demonstrating its use with DISC1 gene analysis across multiple datasets.

Integrative Omics for Informed Drug Repurposing: Targeting CNS Disorders

This paper reviews signature-based in silico approaches for drug repurposing in CNS disorders, integrating data science platforms to improve clinical relevance and address regulatory and knowledge challenges.