Dissecting the functions of NIPBL using genome editing: The importance of the N-terminus of NIPBL in transcriptional regulation
Kosuke Izumi, Kazuhiro Akiyama, Katsunori Fujiki, Koji Masuda, Ryuichiro Nakato, Aiko Iwata‐Otsubo, Masashige Bando, Katsuhiko Shirahige
This study uses CRISPR/Cas9 to generate NIPBL mutants and shows that the N-terminus of NIPBL is critical for transcriptional regulation by interacting with MAU2.
bioRxiv · May 10, 2019 · PreprintGenetics