LC-MS analysis of RNA through hydrogen bonding of alkylamines
Robert L. Ross, Michael J. Sutton, Keeley Murphy, Roberto C. Gamez, Min Du, Michael G. Bartlett
This study demonstrates that hydrogen bond donating alkylamines improve the purity analysis of oligonucleotides using LC-MS by reducing the need for fluoroalcohol reagents.
bioRxiv · Mar 18, 2025 · PreprintBiochemistry