Spatial Organization of Lipids Drives GPCR Conformational Equilibria
Anuradha V. Wijesekara, Jing-Jing Ji, Nessa Pesaran Afsharian, Keen Zhang, Naveen Thakur, Arka Prabha Ray, Bar Elmaleh, Niloofar Gopal Pour, Edward R. Lyman, Matthew T. Eddy
The paper investigates how lipid organization in nanodiscs affects GPCR conformational states, finding that anionic lipid concentration thresholds vary between POPS and POPG.
bioRxiv · Jun 12, 2026 · PreprintBiophysics