Edward R. Lyman

The paper shows that ether linkages in phospholipids modulate membrane mechanics and topology through distinct physical mechanisms, explaining their evolutionary conservation and biological roles.

The paper investigates how lipid organization in nanodiscs affects GPCR conformational states, finding that anionic lipid concentration thresholds vary between POPS and POPG.

The paper develops an investigator-blind analysis pipeline to identify structural elements controlling GPCR function using molecular dynamics simulations and finds known microswitches and two potential new motifs.

This paper uses simulations to show that highly ordered lipid bilayers exhibit glass-like dynamics with soft fluid channels, which may facilitate molecular interactions.

The paper shows that running in mice changes spontaneous neural activity in the olfactory bulb, increasing population entropy and suggesting higher-order neuron interactions during locomotion.