Tauopathy severely disrupts homeostatic set-points in emergent neural dynamics but not in the activity of individual neurons.
James N. McGregor, Clayton A. Farris, Sahara Ensley, Aidan M Schneider, Chao Wang, Yuqi Liu, Jianhong Tu, Halla Elmore, Keenan D. Ronayne, Ralf Weßel, Eva L. Dyer, Kiran Bhaskaran‐Nair, David M. Holtzman, Keith B. Hengen
This study shows that tauopathy disrupts network-level homeostatic set-points in hippocampal activity but not individual neuron activity, with implications for computational capacity and behavior.
bioRxiv · Sep 1, 2023 · PreprintNeuroscience