Mutation-selection-drift balance models of complex diseases
Jeremy J. Berg, Xinyi Li, Kellen Riall, Laura K. Hayward, Guy Sella
The paper develops a mutation-selection-drift balance model for complex diseases, finding that directional selection has little role in common variation but may affect rare variants, and suggests heritability estimates may be biased.
Genetics · Oct 10, 2025Peer-reviewedGenetics