Jeremy J. Berg

The paper compares the effects of mutational drought and meltdown on extinction risk in small populations, finding mutational drought is more significant in stable and changing environments.

This paper investigates how background selection affects complex trait evolution under different phenotypic selection models, showing that genetic variance changes depend on the relationship between phenotype and fitness.

This paper quantifies how polygenic scores are affected by ancestry stratification using a theoretical framework and applies it to UK Biobank data.

The paper develops a mutation-selection-drift balance model for complex diseases, finding that directional selection has little role in common variation but may affect rare variants, and suggests heritability estimates may be biased.

This paper develops a method to protect polygenic score association tests from confounding by ancestry variation using a new approach to estimate population structure.

This paper introduces PGSUS, a method to assess the influence of stratification and assortative mating effects on polygenic scores, revealing that direct genetic effects often contribute little to PGS variation.

This paper shows that allele ages provide limited additional information about the distribution of fitness effects beyond what is already captured by allele frequencies.

This paper quantifies how allelic turnover affects polygenic score accuracy in ancient samples using theoretical models and simulations.

The paper explains that population genetic measures like pLI reflect selection on heterozygotes, not dominance or haploinsufficiency.