Hepatic huntingtin loss drives an acute phase response and liver injury in multiple mouse models
Colby L. Samstag, Robert M. Bragg, Kelsie Neumann, Ella W. Mathews, Kellie Lam, Christine C Wu, Deanna M. Marchionini, Michael J. MacCoss, Daniel Raftery, Jeffrey B. Carroll
This study shows that reducing huntingtin in the liver causes inflammation and damage, highlighting safety concerns for HTT-lowering therapies.
bioRxiv · Jul 29, 2026 · PreprintMolecular Biology