Daniel Raftery

Hepatic huntingtin loss drives an acute phase response and liver injury in multiple mouse models

This study shows that reducing huntingtin in the liver causes inflammation and damage, highlighting safety concerns for HTT-lowering therapies.

Dogs and humans share biomarkers of mortality

The paper identifies shared plasma metabolomic biomarkers of mortality in dogs and humans, showing strong correlations between metabolite effects on all-cause mortality in both species.

Multi-omic integration reveals dynamic changes in human placental metabolism across gestation

The paper integrates metabolomic and transcriptomic data to identify dynamic changes in placental metabolism across trimesters in human pregnancy.

Protein catabolites as blood-based biomarkers of aging physiology: Findings from the Dog Aging Project

The paper identifies post-translationally modified amino acids (ptmAAs) as age-related plasma metabolites in dogs, linking them to kidney function and dietary factors.

Selection for early reproduction leads to accelerated aging and extensive metabolic remodeling in Drosophila melanogaster

This study uses metabolomic profiling in Drosophila melanogaster to show that selection for early reproduction leads to repeatable metabolic changes and a reliable predictor of biological age.

Functional Specialization of S-Adenosylmethionine Synthases Links Phosphatidylcholine to Mitochondrial Function and Stress Survival

The paper investigates the functional specialization of SAM synthases in C. elegans, showing that SAMS-1 affects mitochondrial function and stress survival through phosphatidylcholine, while SAMS-4 is critical for methylation reactions.

Systems biology and machine learning approaches identify metabolites that influence dietary lifespan and healthspan responses across flies and humans.

Natural Variation in Age-Related Dopamine Neuron Degeneration is Glutathione-Dependent and Linked to Life Span

This study identifies glutathione deficiency as a key factor in age-related dopamine neuron loss and links it to lifespan in Drosophila, with implications for human Parkinson's disease.

An aging clock using metabolomic CSF

This paper develops a metabolomic age prediction model using CSF data from healthy humans and applies it to Alzheimer's and Parkinson's patients, finding increased prediction error in disease cohorts.

Calorie Restriction Prevents Age-Related Changes in the Intestinal Microbiota

This study shows that calorie restriction in mice increases microbial diversity and prevents age-related microbiome changes, maintaining a younger microbial and metabolite profile.

MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis

This paper shows MLX and MondoA are essential for male fertility and tumor survival, with MLX regulating metabolism, stress, and germ cell development.