Neuronal Activity-Dependent Gene Dysregulation in C9orf72 i3 Neuronal Models of ALS/FTD Pathogenesis
Layla Ghaffari, Emily M. Welebob, Sarah E. Bond Newton, Ashley V. Boehringer, Kelly Cyliax, Piera Pasinelli, Davide Trotti, Aaron R. Haeusler
This study shows that C9orf72 repeat expansion neurons have altered transcriptomes under different stimulation conditions, revealing activity-dependent gene dysregulation in ALS/FTD.
American Journal of Physiology-Cell Physiology · Aug 28, 2025Peer-reviewedNeuroscience