Author

Ken Chen

The University of Texas MD Anderson Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1

Frequent Co-Authors

André KahlesiD· 2 shared Ekta KhuranaiD· 2 shared Hidewaki NakagawaiD· 2 shared Jakob Skou PederseniD· 2 shared Jan O. KorbeliD· 2 shared Kjong-Van LehmanniD· 2 shared Morten Muhlig NielseniD· 2 shared Nuno A. FonsecaiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

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10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

André KahlesORCID

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3 papers

Recent·Most cited

PPP1R3G Deletion Blocks RIPK1-Mediated Apoptosis and Necroptosis in Doxorubicin-Induced Cardiotoxicity

Xueling Ma, Ken Chen, Zhigao Wang

This study identifies PPP1R3G as a critical amplifier of doxorubicin-induced cardiotoxicity by promoting RIPK1-mediated apoptosis and necroptosis.

Proceedings of the National Academy of Sciences · Apr 15, 2026Peer-reviewedMolecular Biology

Unique genomic features and deeply-conserved functions of long non-coding RNAs in the Cancer LncRNA Census (CLC)

Joana Carlevaro-Fita, Andrés Lanzós, Lars Feuerbach, Chen Hong, David Mas-Ponte, Jakob Skou Pedersen, PCAWG Drivers and Functional Interpretation Group, Federico Abascal, Samirkumar B. Amin, Gary D. Bader, Jonathan Barenboim, Rameen Beroukhim, Johanna Bertl, Keith A. Boroevich, Søren Brunak, , S. Cenk Şahinalp

The paper introduces the Cancer LncRNA Census (CLC), a curated resource of lncRNAs with causative roles in cancer, and shows their genomic and evolutionary features.

Communications Biology · Feb 5, 2020Peer-reviewedGenomics

Whole genome and RNA sequencing of 1,220 cancers reveals hundreds of genes deregulated by rearrangement of cis-regulatory elements

Yiqun Zhang, Fengju Chen, Nuno A. Fonseca, Yao He, Masashi Fujita, Hidewaki Nakagawa, Zemin Zhang, Alvis Brāzma, PCAWG Transcriptome Working Group, Samirkumar B. Amin, Philip Awadalla, Peter J. Bailey, Alvis Brazma, Angela Norie Brooks, Claudia Calabrese, , Paul Alan Edwards

The paper identifies hundreds of genes deregulated by SVs in cancer, showing increased expression linked to SV breakpoints and enhancer elements.

Nature Communications · Feb 5, 2020Peer-reviewedGenomics