Highly Sequence-specific, Timing-controllable m6A Demethylation by Modulating RNA-binding Affinity of m6A Erasers
Kenko Otonari, Yuri Asami, Kosuke Ogata, Yasushi Ishihama, Shiroh Futaki, Miki Imanishi
This study develops a timing-controllable m6A demethylation tool with reduced off-target effects by combining PUF RNA-binding proteins with m6A-erasers and a rapamycin-based switch.
Chemical Communications · Oct 22, 2024Peer-reviewedBiochemistry