Kenneth L. Beattie

Addition of 2', 3' cis-dialdehydes, 2', 3' cis-diols and phosphoryl groups to the 3' end of oligonucleotides using periodate-oxidized nucleoside triphosphates and terminal deoxynucleotidyl transferase

This paper introduces a method to modify the 3' end of oligonucleotides with cis dialdehydes, phosphoryl groups, or cis diols using periodate-oxidized nucleotides and TdT, demonstrating its application in protein-DNA interaction studies.