Assessing Codon Language Models for Context-Aware Codon Optimization in Nucleic Acid-Based Medicines
Shushan Toneyan, Kerstin Scholz, Carlo De Donno, Florian Noack, Simon Ausländer, Tony Cijsouw, Joshua L. Payne
This study benchmarks three codon language models for optimizing nucleic acid-based medicines, finding that while no single model excels across all tasks, they offer advantages in capturing translational context beyond codon frequency.
bioRxiv · Aug 19, 2026 · PreprintBioinformatics