Author

Khalid Chakir

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:DNA methylation· 1 Assay:proteomics· 1

Frequent Co-Authors

Edward G. LakattaiD· 3 shared Jia-Hua QuiD· 3 shared Kirill V. TarasoviD· 3 shared Allwin Jennifa Silvester· 1 shared Daniel R. RiordoniD· 1 shared Maria Grazia PerinoiD· 1 shared Yelena S. Tarasova· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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3 shared papersSystems Biology

Edward G. LakattaORCID

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3 papers

Recent·Most cited

Cardiac Specific Overexpression of Adenylyl Cyclase 8 Reprograms the Mouse Sinoatrial Node Transcriptome

Jia-Hua Qu, Kirill V. Tarasov, Khalid Chakir, Edward G. Lakatta

This study identifies transcriptomic changes in the sinoatrial node of mice overexpressing AC8, revealing altered pathways and transcription factors linked to cardiac aging and disease.

Biophysical Journal · Feb 1, 2024Peer-reviewedSystems Biology

Reprogramming of cardiac phosphoproteome, proteome and transcriptome confers resilience to chronic adenylyl cyclase-driven stress

Jia-Hua Qu, Khalid Chakir, Kirill V. Tarasov, Daniel R. Riordon, Maria Grazia Perino, Allwin Jennifa Silvester, Edward G. Lakatta

The paper integrates phosphoproteomics, proteomics, and transcriptomics to show that reprogramming of cardiac signaling pathways enhances resilience to chronic adenylyl cyclase stress.

eLife · Jul 26, 2023Peer-reviewedBioinformatics

Transcriptome of left ventricle and sinoatrial node in young and old C57 mice

Jia-Hua Qu, Kirill V. Tarasov, Yelena S. Tarasova, Khalid Chakir, Edward G. Lakatta

The paper compares age-related molecular changes in left ventricle and sinoatrial node cells from young and old C57 mice using transcriptomic analysis to identify age-associated gene expression patterns and regulatory mechanisms.

Fortune Journal of Health Sciences · Jan 1, 2023Peer-reviewedSystems Biology