EnsPlex: Integrative Protein Complex Prediction through Multi-source Complementary Structural Sampling and Topology-Aware Candidate Selection
Baochuan Hu, Zhenhua Lu, Khalid Zaman, Zhaoxi Sun, Xiao He
EnsPlex improves protein complex structure prediction by integrating multi-source sampling and topology-aware candidate selection, achieving a 27.8% relative improvement over AlphaFold3 in antigen-antibody systems.
bioRxiv · Oct 2, 2026 · PreprintBioinformatics