Xiao He

Acetylation of NDUFA13 at K7 Senses OXPHOS Dysfunction to Disrupt Prohibitin Scaffolds and Drive Cristae Remodelling in Heart Failure

This study identifies NDUFA13-K7 acetylation as a sensor linking OXPHOS dysfunction to cristae remodelling and metabolic changes in heart failure.

EnsPlex: Integrative Protein Complex Prediction through Multi-source Complementary Structural Sampling and Topology-Aware Candidate Selection

EnsPlex improves protein complex structure prediction by integrating multi-source sampling and topology-aware candidate selection, achieving a 27.8% relative improvement over AlphaFold3 in antigen-antibody systems.

OmniSyn unifies target-aware molecular generation and optimization within a synthesis-native LLM framework across the human proteome

OmniSyn generates and optimizes target-specific molecules with synthesis traces using a sequence-conditioned LLM, achieving state-of-the-art performance on drug discovery benchmarks.

19F Ultrafast MAS NMR Reveals the Dynamic Basis of pH-Dependent Regulation in Proteorhodopsin

This paper uses 19F ultrafast MAS NMR to study pH-dependent dynamics in proteorhodopsin, revealing the role of specific residues in proton transport and photocycle regulation.

A Mouse-adapted SARS-CoV-2 Model for Investigating Post-acute Sequelae of COVID infection

This study uses a mouse-adapted SARS-CoV-2 strain to model long-term post-acute sequelae of COVID-19, finding persistent neurological and multi-organ impairments in mice after mild infection.