RNA polymerase II CTD Ser5 phosphorylation induces competing effects of expansion and compaction
Maurice Cohen, Wei Chen, Sophia M. Dewing, William P. Barr, Kian A. Sethi, Ray East, Oluebube C. Onwuzulu, Scott A. Showalter, K. Aurelia Ball
This study uses molecular dynamics simulations to show that Ser5 phosphorylation of RNA Polymerase II CTD causes both expansion and compaction through electrostatic repulsion and cis-Pro6 stabilization.
Biophysical Journal · Jan 14, 2026Peer-reviewedBiophysics