Scott A. Showalter

Residue-level mapping of crowding effects on protein phase separation

This study investigates how different crowding agents affect protein phase separation using NMR, revealing residue-level environmental influences and highlighting the importance of crowder identity.

RNA polymerase II CTD Ser5 phosphorylation induces competing effects of expansion and compaction

This study uses molecular dynamics simulations to show that Ser5 phosphorylation of RNA Polymerase II CTD causes both expansion and compaction through electrostatic repulsion and cis-Pro6 stabilization.

Phosphorylation patterns modulate the transient secondary structure of RNA polymerase II CTD without altering its global conformation

Molecular insights into the interaction between a disordered protein and a folded RNA

This study characterizes the RNA-binding properties of a disordered protein, SERF, and shows that binding to RNA causes modest global compaction without inducing structural changes in either molecule.