LINE-1 transposon derived DNA lesions reshape the chromatin landscape to promote genome instability
Arun Kumar, Ankita Subhadarsani Parida, Kiran Bhatoa, Sunil K. Raghav, Bhavana Tiwari
This study shows that LINE-1 endonuclease activity causes DNA damage and chromatin remodelling in melanoma cells, with p53 modulating this process.
bioRxiv · Jun 30, 2026 · PreprintCancer Biology