Sunil K. Raghav

This study shows that LINE-1 endonuclease activity causes DNA damage and chromatin remodelling in melanoma cells, with p53 modulating this process.

This study shows that early glycolysis inhibition enhances Tfh cell differentiation but impairs their function, revealing a glycolysis-fatty acid metabolic axis that controls Tfh function.

The paper presents a comprehensive genomic atlas of Indian populations, identifying novel variants and highlighting genetic diversity and pharmacogenomic implications.

The paper analyzes whole-exome sequencing data from 13 tribal groups in Odisha, India, identifying genetic structure, rare variants, and clinically relevant pathogenic variants.

This study identifies NEK9 as a driver of docetaxel resistance in cancers and shows that its ablation sensitizes cells to docetaxel via ERK-mediated pyroptosis, suggesting fostamatinib as a potential therapeutic partner.

The paper analyzes intra-host Single Nucleotide Variations (iSNVs) in SARS-CoV-2 genomes across multiple time points and regions, finding that many iSNVs later become population-level variants and some may contribute to immune escape.

The paper analyzes SARS-CoV-2 genome sequences from Indian isolates, identifies clade distribution and transmission routes, and shows the D614G mutation enhances spike protein interaction with TMPRSS2, increasing viral infectivity.

The paper sequences 1000 SARS-CoV-2 genomes from India, revealing multiple circulating lineages, predominant A2a haplotype with D614G mutation, and geographic mutation clustering.