Diverging Parkinson's Disease Pathology between GBAN370S ,LRRK2G2019S and engineered SNCAA53T iPSC-derived Dopaminergic Neurons
Ali Fathi, Kiranmayee Bakshy, Lida Zieghami, Rebecca Fiene, Robert Bradley, Sarah Dickerson, Coby B. Carlson, Scott J. Schachtele, Jing Liu
This study compares dopamine neuron phenotypes from PD patients with mutations in GBAN370S and LRRK2G2019S to engineered SNCAA53T iPSC-derived neurons, revealing divergent pathogenic mechanisms and potential therapeutic targets.
bioRxiv · Jan 6, 2023 · PreprintNeuroscience